Nasdaq · SYRE · stock
Spyre Therapeutics, Inc. (SYRE) stock price history
Every Nasdaq trading session of Spyre Therapeutics, Inc. from Apr 7, 2016 to Nov 12, 2026: 2,667 daily bars, adjusted for splits and dividends, with minute bars from Jul 13, 2026 forward. The full series is served by the API: a free key covers the last year, paid plans the whole history and minute bars.
SYRE adjusted close, 2016 to 2026
- $299.75
- All time high, 2016
- $110.64
- 52 week high, $22.13 low
- 2,667
- Daily sessions since 2016
Last updated Nov 12, 2026, the last stored session. Refreshes after each trading day. Full 2016 to 2026 series and minute bars.
SYRE key facts
- Spyre Therapeutics, Inc. (SYRE) closed at $102.91 on Nov 12, 2026 on Nasdaq.
- SYRE's all time high close is $299.75, set on Apr 8, 2016; its all time low close is $2.65 on Jun 21, 2023.
- SYRE's 52 week range is $22.13 to $110.64.
- SYRE returned +339.2% over the year to Nov 12, 2026 and -41.5% over five years.
- Over ten years SYRE returned -31%, -3.6% a year compounded.
- SYRE's deepest drawdown was -99.1% from Apr 8, 2016 to Jun 21, 2023.
- DataCedar holds 2,667 daily sessions of SYRE history from Apr 7, 2016 and minute bars from Jul 13, 2026, adjusted for splits and dividends, served by the API under a key.
SYRE price chart, 2016 to 2026
SYRE returns
Price return from the last close on or before the window start to Nov 12, 2026, on adjusted closes.
| Period | Return |
|---|---|
| 1 month | +19.8% |
| 3 months | -1.1% |
| 6 months | +37.1% |
| Year to date | +222.8% |
| 1 year | +339.2% |
| 3 years | +984.4% |
| 5 years | -41.5% |
| 10 years | -30.6% |
| Since Apr 7, 2016 | -57.9% |
| Compound annual growth, 10.6 years | -7.8% |
SYRE records
Measured on the stored closes; every figure is reproducible from the API series.
- All time high close
- $299.75 on Apr 8, 2016
- All time low close
- $2.65 on Jun 21, 2023
- 52 week high
- $110.64 on Nov 9, 2026
- 52 week low
- $22.13 on Nov 14, 2025
- Deepest drawdown
- -99.1% from Apr 8, 2016 to Jun 21, 2023, not yet recovered
- Best single session
- +330.2% on Jun 22, 2023
- Worst single session
- -66.0% on Nov 30, 2022
- Volatility, 1 year annualised
- 65.4%
- Sessions closing higher, 1 year
- 53%
- Best calendar year
- 2023, +91%
- Worst calendar year
- 2022, -91%
SYRE price history by year
Open is the first session's open, high and low span the year, close is the last session's close, and the return is close over the previous year's close. 2016 starts on Apr 7, 2016; 2026 runs to Nov 12, 2026.
| Year | Open | High | Low | Close | Return | Volume | Sessions |
|---|---|---|---|---|---|---|---|
| 2026 | $32.76 | $110.64 | $28.00 | $102.91 | +214.1% | 246.1M | 218 |
| 2025 | $23.60 | $35.31 | $10.91 | $32.76 | +40.7% | 173.2M | 250 |
| 2024 | $21.99 | $47.97 | $18.54 | $23.28 | +8.2% | 132.4M | 252 |
| 2023 | $10.88 | $24.00 | $2.65 | $21.52 | +91.3% | 25.1M | 250 |
| 2022 | $119.75 | $120.75 | $8.50 | $11.25 | -90.5% | 13.1M | 251 |
| 2021 | $199.00 | $219.75 | $86.75 | $118.75 | -39.6% | 2.1M | 252 |
| 2020 | $185.75 | $284.50 | $87.50 | $196.75 | +3.0% | 2.2M | 253 |
| 2019 | $184.50 | $236.25 | $149.75 | $191.00 | +2.0% | 1.3M | 252 |
| 2018 | $136.00 | $300.00 | $123.75 | $187.25 | +38.4% | 1.9M | 251 |
| 2017 | $109.00 | $203.50 | $70.25 | $135.25 | +24.4% | 659.6K | 251 |
| 2016 | $250.00 | $318.75 | $97.25 | $108.75 | n/a | 437.7K | 187 |
SYRE monthly closes, last 12 months
| Month | Month end close | Change |
|---|---|---|
| November 2026 | $102.91 | +6.6% |
| October 2026 | $96.56 | +8.5% |
| September 2026 | $89.03 | -0.3% |
| August 2026 | $89.33 | -9.2% |
| July 2026 | $98.33 | +10.8% |
| June 2026 | $88.78 | +20.8% |
| May 2026 | $73.50 | -1.3% |
| April 2026 | $74.45 | +47.6% |
| March 2026 | $50.44 | +17.3% |
| February 2026 | $43.01 | +34.5% |
| January 2026 | $31.98 | -2.4% |
| December 2025 | $32.76 | +9.2% |
About the SYRE data
Daily bars. 2,667 sessions from Apr 7, 2016 to Nov 12, 2026, one row per Nasdaq trading day with open, high, low, close and volume. Prices are adjusted for splits and cash dividends so the series is comparable across its whole length; the API also serves the raw, split only and dividend only views.
Minute bars. Stored from Jul 13, 2026 forward, most recent session Oct 23, 2026. Minute history is captured from the day collection began and is never backfilled, so this start date is exact. Five minute, fifteen minute and hourly bars are derived from these minutes.
Time and currency. Session dates are Nasdaq trading days; minute timestamps are UTC. Prices are in USD. Volume is shares traded on the session.
Get the data. The REST endpoint returns the daily series as JSON with pagination; a free key serves the last year, Quant and above the full history back to Apr 7, 2016, and minute bars come with the paid windows. It takes timeframe (1Min, 5Min, 15Min, 1Hour, 1Day), adjustment, start and end. See the bars endpoint and authentication, and pricing for the plan windows.
curl "https://api.datacedar.com/v3/stocks/nasdaq%3ASYRE/bars?timeframe=1Day&adjustment=all&limit=50000" \
-H "X-API-Key: YOUR_KEY"Nearby on Nasdaq
Common questions
SYRE share price history
